Multi-faceted substrate specificity of heparanase

Multi-faceted Visualisation of Worklists

Although business process management has been a major area of ICT research, no coherent approach has been developed to address the problem of business process visualisation to aid workers in the process of task prioritisation. In this paper we describe the development of a new, coherent approach to worklist visualisation, via analysis and development of a resource-centric view of the worklist i...

Substrate Specificity of MMPs

Activity and tumor specificity of human heparanase gene core promoter.

Heparanase (HPSE) plays a critical role in tumor metastasis and vascularization. In addition, the human HPSE promoter has been cloned and characterized. However, the activity and specificity of the HPSE promoter in tumor cells remains unclear. The core fragment of the HPSE promoter was amplified and cloned into the multiple cloning site of the pEG...

The substrate specificity of fumarase.

The substrate specificity of fumarase has been studied by measuring the ability of the enzyme to hydrate or dehydrate derivatives of fumarate and L-malate. Fumarase was observed to hydrate fumarate and its derivatives in the order, fluorofumarate > fumarate > chlorofumarate > bromofumarate > acetylenedicarboxylate > iodofumarate > mesaconate. With the exception of fluorofumarate, water was adde...

2 Substrate Specificity of MMPs